Different letters could mean things like different gearbox set ups and that though, or even the same letter but different software revision can mean that, or the difference between one ecu running narrowband and one wideband, one a K03S turbo and one a K04 etc.
If you can find out if the ecu or car set up for that specific ecu matches your's pretty much the same, then usually a lot of them can be crossed flashed. I cross flashed a Tiptronic file to my manual once to see if it would work (AUQ), it did but I'm pretty sure there were some changes the ecu didn't like, so I didn't leave it on for more than a couple of minutes, I just wanted to know if it would work!!