The issues is you're trying to connect to COM2 which doesn't seem to exist.
Use the FTDI option or change the COM port to the one your cable uses. Since it's a new computer the COM # more then likely changed as well.
Thanks VR this seems to be an ongoing issue and it finally let me flash with the Nef software and then log with the GUI from ME& logger without changing the driver. Before even after I got it to work Id have to flash, then change drivers to log. The damn thing gave me hell tonight! I restarted the computer 3 times figuring it out and finally just poof it's all good and I'm back to normal. I never could understand these things. Whatever I guess I'm ok with that and I thank everyone for their help